Cross Talk of Purinergic and Immune Signaling: Implication in Inflammatory and Pathogenic Diseases

Purine derivatives like adenosine 5′-triphosphate (ATP) is the powerhouse of cell and essential to maintain cellular homeostasis activity. Besides this they also act as a chemical messenger when released into extracellular milieu because stress insult. The ATP (eATP) well its metabolite triggers purinergic signaling affecting various processes such cytokine chemokine production, immune function, differentiation, maturation, mediates inflammatory Aberrant had been implicated in several diseased conditions. This chapter will focus on dynamics driving under conditions autoimmunity infectious disease.